Electrophoretic studies of plasma proteins in normal children.
نویسندگان
چکیده
By ELIZABETH L. KNAPP, PH.D., AND JOSEPH I. ROUTH, PH.D. Iowa City, Iowa E LECTROPHORETIC analysis has been widely used in recent years as a method of study of the various components of the plasma proteins. The method has proved to be a valuable tool in the study of a great many diseases in which marked deviations from the normal electrophoretic pattern of plasma occur. For evaluation of the changes occurring in disease, the electrophoretic pattern of plasma proteins in healthy adult men has been used as the standard of comparison. Studies on normal men reported from different laboratories show good agreement for percentage distribution of protein fractions. Although Longsworth and co-workers’ have shown that the newborn infant has an unusually high 1’-globulin concentration, few studies in children which would determine changes in electrophoretic pattern with increasing age have been reported. Recently as a part of a study of immunologic and biochemical factors in the etiology of rheumatic fever, Lubschez2 published electrophoretic analyses of plasma proteins in 30 healthy children between the ages of 2 and 1 1 years. Of primary interest to the author was the effect of antecedent infection on the normal pattern. Lubschez noted that the relative concentration of the various protein fractions was similar to normal adult values, although the percentage of albumin tended to be somewhat higher and the percentage of -globulin somewhat lower in the younger children. The present study was undertaken to establish the normal electrophoretic patterns for
منابع مشابه
بررسی ترکیبات گلیکوزیله نهایی آلبومین سرم (AGE) در افراد دیابتی به روش ایزوالکتریک فوکوسینگ (IEF) و فلورسانس جهت ارزیابی پیشرفت بیماری دیابت
Background: The non-enzymatic glycosylation (NEG) of proteins in diabetes damages both the structure and function of these proteins. In vivo and in vitro studies have shown that NEG of proteins and advanced glycosylation end-products (AGE) contribute to the pathogenesis of both macrovascular, such as atherosclerosis, and microvascular complications, such as retinopathy and nephropathy, in diabe...
متن کاملSerum Alpha-1-antitrypsin Evaluation by Three Electrophoretic, Enzymatic and Immunodiffussion Methods
Abstract Background & Objective: Alpha-1-antitrypsin (AAT) is the major component of the human plasma alpha-1 globulin proteins and acts as a major inhibitor of proteolytic enzymes, particularly elastase. AAT deficiency is accompanied by lung, liver and other disorders, therefore, AAT is clinically important and its precise evaluation is diagnostically critical. In present study serum AAT was e...
متن کاملElectrophoretic Profile of Albumin, α1, α2, β and γ Globulin in Sera of Opioid Dependants and Non-dependants
Div-salaar K1, Saravani R2, Shamsi-e-meimandi M3, Taei M4, Sheikholeslami A5 1. MSc. Staff member of Neurology Sciences Research Center, Kerman University of Medical Sciences 2. Instructor, Department of Biochemistry, Faculty of Medicine, Zahedan University of Medical Sciences 3. Instructor, Department of Physiology and Pharmacology, Faculty of Medicine, Neurology Sciences Research Center, Karm...
متن کاملPlasma Protein Metabolism—electrophoretic Studies
The findings on electrophoretic analysis of plasma proteins during many weeks of low protein feeding in dogs accord in general with those of chemical analysis as concerns the alterations in plasma albumin and globulin concentrations. Long continued restriction of dietary protein results in decreased albumin levels while plasma globulin concentrations remain essentially normal. The degree of dep...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Pediatrics
دوره 4 4 شماره
صفحات -
تاریخ انتشار 1949